DryFlowEx PNH High-Sensitivity Assay Kit

• VD reagent kit following the current ICCS/ESCCA guidelines
• High-sensitivity detection of PNH clones in erythrocytes, monocytes, and neutrophils
• Allows evaluation of clone size in erythrocytes

Reliable detection

Flow cytometry is considered the gold standard for the detection of Paroxysmal Nocturnal Haemoglobinuria (PNH) clones, thus playing an important role in the diagnosis, monitoring, and clinical management of patients with PNH. The most recent update of the ICCS/ESCCA consensus guidelines [1] allows sensitive and accurate detection of even minor PNH clones.

Testing population

Patients with:

• laboratory markers of haemolysis, when other more common causes of haemolysis have been excluded,
• unexplained thromboses at a young age, diagnosed thromboses in an unusual site,
• inherited or acquired aplastic anaemia (AA), myelodysplastic syndrome (MDS),
• unexplained cytopenia in whom AA or MDS are differential diagnostic considerations [2]

Your benefits in daily routine

our benefits in daily routine

• The standardisation and convenience afforded by an IVD kit
• Assurance that you are working according to the most recent guidelines, which allows for a high level of detection sensitivity, in part, due to the inclusion of
• FLAER (Alexa Fluor™ 488-labelled proaerolysin) Ready when you need it – dry format reagents are stable and ready when a sample comes in

REFERENCES

1. Illingworth AJ, Marinov I, Sutherland DR (2019): Sensitive and accurate identification of PNH clones based on ICCS/ESCCA PNH Consensus Guidelines-A summary. Int J Lab Hematol; 41 Suppl 1: 73–81. doi: 10.1111/ijlh.13011. PMID: 31069981.
2. Borowitz, MJ et al. (2010): Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry B Clin Cytom.; 78(4): 211–30. doi: 10.1002/cyto.b.20525.